Recognition for research team from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences and the Faculty of Biology of the University of Gdańsk | University of Gdańsk

Recognition for research team from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences and the Faculty of Biology of the University of Gdańsk

Research teams from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences and the Faculty of Biology of the University of Gdańsk have received recognition from the Polish Academy of Sciences for a series of articles concerning the application of flavonoids in the treatment of genetically conditioned diseases. The research by both teams has led to the discovery of the exact influence of these compounds on the human system, which may in future result in the effective treatment of diseases with metabolic and lysosomal defects, including metabolic diseases of affluence such as diabetes, obesity or atherosclerosis as well as common neurodegenerative diseases such as Parkinson’s or Alzheimer’s disease.

Research teams from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences affiliated with the University of Gdańsk and the Faculty of Biology of the University of Gdańsk have been recognised by Division II: Biological and Agricultural Sciences of the Polish Academy of Sciences for a series of articles entitled “The Specific Application of Flavonoids in the Therapy of Genetically Conditioned Metabolic Diseases from the Lysosomal Storage Diseases Group (LSDs)”.

The teams comprise Prof. Magdalena Gabig-Cimińska from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences; Prof. Grzegorz Węgrzyn from the UG’s Faculty of Biology ─ Corresponding Member of the Polish Academy of Sciences; Prof. Joanna Jakóbkiewicz-Banecka from the UG’s Faculty of Biology and Dr Marta Moskot from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences.

The distinguished research concerns the specific application of flavonoids in the therapy of genetically conditioned metabolic diseases from the lysosomal storage diseases group (LSDs) i.e. fatal diseases caused by a genetic defect resulting in a deficiency or a lack of enzymes of key importance to the proper functioning of the human system. Flavonoids, polyphenol compounds which are secondary products of plant metabolism, amongst others found in vegetables, fruit, tea, cocoa or wine, for centuries have constituted a crucial element of the diet of the inhabitants of Asia and are also responsible for the so-called “French paradox” i.e. for the beneficial aspects of moderate consumption of red wine. The work of the team from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences and the Faculty of Biology of the University of Gdańsk has allowed for the discovery of the exact influence of these compounds on the human system, particularly in the context of their potential application in the treatment of LSDs. In the course of the research, the factors and processes influencing the course of these diseases have been described. In addition, a gene-expression pattern has been documented i.e. a transcription of human skin cells exposed to flavonoids, which has played a significant role in explaining the molecular effect of these compounds on cell processes.

The distinguished work of both teams comprises research issues unique on a global scale and related to the potential application of natural compounds in the treatment of severe diseases with a genetic background. The attempt to develop new medication is of vital importance from the medical and social aspect and is often the only hope for patients and their families. What is the most important is the fact that this work constitutes a new chapter in the research into these compounds as potential therapeutic agents, also for many different diseases with lysosomal disfunction, including metabolic diseases of affluence such as diabetes, obesity or atherosclerosis as well as common neurodegenerative diseases such as Parkinson’s or Alzheimer’s disease. 

 

Research teams
Last modified by: Tadeusz Zaleski
Created by: Tadeusz Zaleski
Last modified: 
2017, January 3 - 10:39am